Two dominant mutations in the mouse fused gene are the result of transposon insertions.

doi:10.1093/genetics/147.2.777

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Article

Two dominant mutations in the mouse fused gene are the result of transposon insertions.

Genetics - 1 Oct 1997

Vasicek T J, Zeng L, Guan X J, Zhang T, Costantini F, Tilghman S M

Abstract excerpt

The mouse Fused locus encodes a protein that has been implicated in the regulation of embryonic axis formation. The protein, which has been named Axin to distinguish it from the product of the unrelated Drosophila melanogaster gene fused, contains regions of similarity to the RGS (regulators of G...

Topics

Animals
Axin Protein
Base Sequence
DNA
Genes, Dominant
Homozygote
Mice
Mutation
Proteins
RNA, Messenger
Repressor Proteins
Retroelements
Transcription, Genetic

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