Article
Phenotypic and molecular analysis of a transgenic insertional allele of the mouse Fused locus.
Genetics - 1 Sept 1995
Perry W L, Vasicek T J, Lee J J, Rossi J M, Zeng L, Zhang T, Tilghman S M, Costantini F
Abstract excerpt
Spontaneous mutations at the mouse Fused (Fu) locus cause dominant skeletal and neurological defects and recessive lethal embryonic defects including neuroectodermal abnormalities and axial duplications. Here, we describe a new allele at the Fu locus caused by a transgenic insertional mutation, H...
Topics
- Alleles
- Animals
- Base Sequence
- Chromosome Mapping
- Cloning, Molecular
- DNA Primers
- DNA Transposable Elements
- Female
- Genes, Lethal
- Homozygote
- Humans
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Mice, Transgenic
- Molecular Sequence Data
- Mutagenesis, Insertional