Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An N-ethyl-N-nitrosourea screen for genes involved in variegation in the mouse.

Proceedings of the National Academy of Sciences of the United States of America - 24 May 2005

Blewitt Marnie E, Vickaryous Nicola K, Hemley Sarah J, Ashe Alyson, Bruxner Timothy J, Preis Jost I, Arkell Ruth, Whitelaw Emma

Abstract excerpt

We have developed a sensitized screen to identify genes involved in gene silencing, using random N-ethyl-N-nitrosourea mutagenesis on mice carrying a variegating GFP transgene. The dominant screen has produced six mutant lines, including both suppressors and enhancers of variegation. All are semidominant and five of the six are homozygous embryonic lethal. In one case, the homozygous lethality depends on sex:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenesis, Genetic
Share to Ethylnitrosourea

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Silencing

Share to Green Fluorescent Proteins

Share to Mutagenesis

Share to Pigmentation

Share to Transgenes

Share to X Chromosome

Source

Open in PubMed Open full text

Identifiers

PMID: 15890782
DOI: 10.1073/pnas.0409375102
PMCID: PMC1140414

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An N-ethyl-N-nitrosourea screen for genes involved in variegation in the mouse.PMID 15890782Read ↗

The use of mouse models to study epigenetics.Semantic proximity Read ↗

An N-ethyl-N-nitrosourea mutagenesis screen for epigenetic mutations in the mouse.Semantic proximity Read ↗

Connecting mammalian genome with phenome by ENU mouse mutagenesis: gene combinations specifying the immune system.Semantic proximity Read ↗

Random mutagenesis of the mouse genome: a strategy for discovering gene function and the molecular basis of disease.Semantic proximity Read ↗

Creating a "hopeful monster": mouse forward genetic screens.Semantic proximity Read ↗

Animal Models to Study Environmental Epigenetics1Semantic proximity Read ↗

Dynamic reprogramming of DNA methylation at an epigenetically sensitive allele in mice.Semantic proximity Read ↗

Real-time resolution of point mutations that cause phenovariance in mice.Semantic proximity Read ↗

A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in developmentSemantic proximity Read ↗

Unraveling innate immunity using large scale N-ethyl-N-nitrosourea mutagenesis.Semantic proximity Read ↗

An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse.Semantic proximity Read ↗

Autosomal dominant mutations affecting X inactivation choice in the mouse.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.