Article
A genetic screen for modifiers of Deformed homeotic function identifies novel genes required for head development.
Development (Cambridge, England) - 1 Sept 1997
Gellon G, Harding K W, McGinnis N, Martin M M, McGinnis W
Abstract excerpt
Only a few genes have been identified that participate in the developmental pathways which modulate homeotic (HOX) protein specificity or mediate HOX morphogenetic function. To identify more HOX pathway genes, we screened for mutations on loci on the Drosophila second chromosome that interact with the homeotic gene Deformed (Dfd). Genetic and molecular tests on the eight genes isolated in the screen place them in...
Topics
- Amino Acid Sequence
- Animals
- DNA-Binding Proteins
- Drosophila Proteins
- Drosophila melanogaster
- Female
- Gene Expression Regulation, Developmental
- Genes, Homeobox
- Genes, Insect
- Genetic Complementation Test