Article
Inhibition of patterned cell shape change and cell invasion by Discs large during Drosophila oogenesis.
Genes & development - 1 Oct 1997
Goode S, Perrimon N
Abstract excerpt
Drosophila Discs large (Dlg) is a tumor suppressor gene whose loss in epithelial tissues causes disrupted cell polarity and increased cell proliferation. A human Dlg homolog, hDlg, has been implicated in tumorigenic processes via its association with the product of the Adenomatous Polyposis Coli...
Topics
- Animals
- Cell Movement
- Cell Size
- Clone Cells
- Drosophila
- Drosophila Proteins
- Female
- Genes, Insect
- Genes, Reporter
- Genes, Tumor Suppressor
- Insect Proteins
- Membrane Proteins
- Microscopy, Confocal
- Mutation
- Nerve Tissue Proteins
- Oocytes
- Oogenesis
- Ovary