Epithelial polarity and cell separation in the neoplastic l(1)dlg-1 mutant of Drosophila.

doi:10.1016/0925-4773(92)90014-b

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Article

Epithelial polarity and cell separation in the neoplastic l(1)dlg-1 mutant of Drosophila.

Mechanisms of development - 1 Mar 1992

Abbott L A, Natzle J E

Abstract excerpt

Lethal (1) discs-large-1 [l(1)dlg-1] is a non-epithelial overgrowth or neoplastic mutant of Drosophila, which results in tumor-like imaginal discs and enlarged larvae that never pupariate. In an ultrastructural analysis we found that the wing discs develop convoluted monolayers of epithelial cells characterized by well-defined apical-basal polarity and that these layered cells secrete large amounts of basement...

Topics

Animals
Basement Membrane
Cell Communication
Cell Death
Cell Differentiation
Cell Division
Cell Polarity
Drosophila Proteins
Drosophila melanogaster
Ecdysone
Epithelium
Extracellular Matrix Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Lethal

Insect Hormones

Larva

Membrane Proteins

Neoplasm Proteins

Neoplasms, Experimental

Source

Open in PubMed

Identifiers

PMID: 1606019
DOI: 10.1016/0925-4773(92)90014-b

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1606019-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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