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Article

Differential positive and negative transcriptional regulation by tamoxifen.

Endocrinology - 1 Feb 1995

Ramkumar T, Adler S

Abstract excerpt

Tamoxifen, a nonsteroidal antiestrogen and breast cancer chemotherapeutic, exhibits both estrogen agonist and antagonist properties. Rat GC3 cells grown under estrogen-free conditions were analyzed for the expression of model luciferase reporter genes, either positively or negatively regulated by estrogens. Expression assays adding tamoxifen alone or in combination with 17 beta-estradiol were performed to...

Topics

Animals
Cell Line
Clomiphene
Estradiol
Gene Expression Regulation
Humans
Luciferases
Mutation
Pituitary Gland
Rats
Receptors, Estrogen
Tamoxifen
Transcription, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transcriptional Activation

Source

Identifiers

PMID: 7835285
DOI: 10.1210/endo.136.2.7835285

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7835285-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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