Article
Elevated triglycerides and low HDL cholesterol in transgenic mice expressing human apolipoprotein A-I(Milano).
Atherosclerosis - 1 Jan 1998
Chiesa G, Stoltzfus L J, Michelagnoli S, Bielicki J K, Santi M, Forte T M, Sirtori C R, Franceschini G, Rubin E M
Abstract excerpt
In general, plasma concentrations of high density lipoproteins (HDL) are inversely related to the incidence of coronary artery disease. One exception to this trend is individuals with apolipoprotein A-I(Milano) (apo A-IM), a molecular variant of apo A-I, which results in very low plasma apo A-I and HDL-cholesterol levels. Despite these low levels, and other lipoprotein defects, individuals with this mutation have...
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