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Article

Apolipoprotein AI transgene corrects apolipoprotein E deficiency-induced atherosclerosis in mice.

The Journal of clinical investigation - 1 Aug 1994

Pászty C, Maeda N, Verstuyft J, Rubin E M

Abstract excerpt

Apolipoprotein E (apo E)-deficient mice are severely hypercholesterolemic and develop advanced atheromas independent of diet. The C57BL/6 strain differs from most inbred strains by having lower HDL concentrations and a high risk of developing early atherosclerotic lesions when fed an atherogenic diet. The relative HDL deficiency and atherosclerosis susceptibility of the C57BL/6 strain are corrected with the...

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Identifiers

PMID: 8040345
DOI: 10.1172/JCI117412
PMCID: PMC296173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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