Article
Apolipoprotein AI transgene corrects apolipoprotein E deficiency-induced atherosclerosis in mice.
The Journal of clinical investigation - 1 Aug 1994
Pászty C, Maeda N, Verstuyft J, Rubin E M
Abstract excerpt
Apolipoprotein E (apo E)-deficient mice are severely hypercholesterolemic and develop advanced atheromas independent of diet. The C57BL/6 strain differs from most inbred strains by having lower HDL concentrations and a high risk of developing early atherosclerotic lesions when fed an atherogenic diet. The relative HDL deficiency and atherosclerosis susceptibility of the C57BL/6 strain are corrected with the...
Topics
- Animals
- Apolipoprotein A-I
- Apolipoprotein E4
- Apolipoproteins E
- Arteriosclerosis
- Female
- Genotype
- Humans
- Lipoproteins, HDL
- Male
- Mice
- Mice, Inbred C57BL