Article
Prognostic implications of c-Ki-ras2 mutations in patients with advanced colorectal cancer treated with 5-fluorouracil and interferon: a study of the eastern cooperative oncology group (EST 2292)
The cancer journal from Scientific American - 1 Jan 2000
Wadler S, Bajaj R, Neuberg D, Agarwal V, Haynes H, Benson A B
Abstract excerpt
PURPOSE: Mutations in c-Ki-ras2 (ras) occur in about 40% of patients with colorectal cancers and occur early in the pathogenesis of this disease. To evaluate the prognostic value of mutations in ras, the Eastern Cooperative Oncology Group (ECOG) conducted a retrospective study (EST 2292) to deter...
Topics
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Combined Chemotherapy Protocols
- Colorectal Neoplasms
- Female
- Fluorouracil
- Genes, ras
- Humans
- Interferons
- Male
- Middle Aged
- Mutation
- Prognosis
- Treatment Outcome