Article
An allelic association implicates myeloperoxidase in the etiology of acute promyelocytic leukemia.
Blood - 1 Oct 1997
Reynolds W F, Chang E, Douer D, Ball E D, Kanda V
Abstract excerpt
Myeloperoxidase (MPO) catalyzes a reaction between chloride and hydrogen peroxide to generate hypochlorous acid and other reactive compounds that have been linked to DNA damage. The MPO gene is expressed at high levels in normal myeloid precursors and in acute myeloid leukemias (AMLs) which are c...
Topics
- Alleles
- Binding Sites
- Cell Transformation, Neoplastic
- DNA Damage
- Disease Susceptibility
- Female
- Gene Frequency
- Genotype
- Humans
- Leukemia, Myelomonocytic, Acute
- Leukemia, Promyelocytic, Acute
- Male
- Neoplasm Proteins
- Peroxidase
- Polymerase Chain Reaction
- RNA, Messenger
- RNA, Neoplasm
- Risk