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Article

An allelic association implicates myeloperoxidase in the etiology of acute promyelocytic leukemia.

Blood - 1 Oct 1997

Reynolds W F, Chang E, Douer D, Ball E D, Kanda V

Abstract excerpt

Myeloperoxidase (MPO) catalyzes a reaction between chloride and hydrogen peroxide to generate hypochlorous acid and other reactive compounds that have been linked to DNA damage. The MPO gene is expressed at high levels in normal myeloid precursors and in acute myeloid leukemias (AMLs) which are clonal derivatives of myeloid precursors that have lost the ability to differentiate into mature blood cells. Two MPO...

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Source

Identifiers

PMID: 9326240

Genes

MPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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An allelic association implicates myeloperoxidase in the etiology of acute promyelocytic leukemia.PMID 9326240Read ↗

An Alu element in the myeloperoxidase promoter contains a composite SP1-thyroid hormone-retinoic acid response element.Semantic proximity Read ↗

Analysis of multiple single nucleotide polymorphisms (SNPs) of myeloperoxidase (MPO) to screen for genetic markers associated with acute leukemia in Chinese Han population.Semantic proximity Read ↗

Association of the G-463A myeloperoxidase gene polymorphism with renal disease in African Americans with systemic lupus erythematosus.Semantic proximity Read ↗

Common genetic variants in the myeloperoxidase and paraoxonase genes and the related cancer risk: a review.Semantic proximity Read ↗

MyeloperoxidaseSemantic proximity Read ↗

Expression of myeloperoxidase and gene mutations in AML patients with normal karyotype: double CEBPA mutations are associated with high percentage of MPO positivity in leukemic blasts.Semantic proximity Read ↗

Genetic, phenotypic and clinical features of acute lymphoblastic leukemias expressing myeloperoxidase mRNA detected by RT-PCR.Semantic proximity Read ↗

Association of myeloperoxidase with ovarian cancer.Semantic proximity Read ↗

A myeloperoxidase polymorphism associated with reduced risk of lung cancer.Semantic proximity Read ↗

Serum myeloperoxidase concentration in a healthy population: biological variations, familial resemblance and new genetic polymorphisms.Semantic proximity Read ↗

Myeloperoxidase: new polymorphisms and relation with lung cancer risk.Semantic proximity Read ↗

Enzyme levels and G-463A polymorphism of myeloperoxidase in chronic lymphocytic leukemia and multiple myeloma.Semantic proximity Read ↗

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