Analysis of multiple single nucleotide polymorphisms (SNPs) of myeloperoxidase (MPO) to screen for genetic markers associated with acute leukemia in Chinese Han population.

Abstract excerpt

Myeloperoxidase (MPO) is an important metabolizing enzyme involved in oxidative stress responses to some environmental carcinogens including benzene, a chemical associated with bone marrow toxicity and leukemia. A novel multiplex polymerase chain reaction (PCR) technique based on adapter-ligation mediated allele-specific amplification (ALM-ASA) is simple, inexpensive and especially useful for multiplex single...

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