Article
Association of myeloperoxidase with ovarian cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jan 2014
Castillo-Tong Dan Cacsire, Pils Dietmar, Heinze Georg, Braicu Ioana, Sehouli Jalid, Reinthaller Alexander, Schuster Eva, Wolf Andrea, Watrowski Rafal, Maki Richard A, Zeillinger Robert, Reynolds Wanda F
Abstract excerpt
Myeloperoxidase (MPO) is an oxidant generating enzyme normally restricted to myeloid cells, however aberrant MPO expression has been found to occur in non-myeloid cells in some disease states. The functional -463GA promoter polymorphism alters MPO expression levels. The -463G is within an SP1 binding site and is associated with higher gene expression. The G allele is most frequent with ~62% of European...
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