Article
Expression of myeloperoxidase and gene mutations in AML patients with normal karyotype: double CEBPA mutations are associated with high percentage of MPO positivity in leukemic blasts.
International journal of hematology - 1 Jul 2011
Tominaga-Sato Shinya, Tsushima Hideki, Ando Koji, Itonaga Hidehiro, Imaizumi Yoshitaka, Imanishi Daisuke, Iwanaga Masako, Taguchi Jun, Fukushima Takuya, Yoshida Shinichiro, Hata Tomoko, Moriuchi Yukiyoshi, Kuriyama Kazutaka, Mano Hiroyuki, Tomonaga Masao, Miyazaki Yasushi
Abstract excerpt
The percentage of myeloperoxidase (MPO)-positive blast cells is a simple and highly significant prognostic factor in AML patients. It has been reported that the high MPO group (MPO-H), in which >50% of blasts are MPO activity positive, is associated with favorable karyotypes, while the low MPO group (≤50% of blasts are MPO activity positive, MPO-L) is associated with adverse karyotypes. The MPO-H group shows...
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