Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detection of the factor VLeiden mutation. Development of a testing algorithm combining a coagulation assay and molecular diagnosis.

American journal of clinical pathology - 1 Oct 1997

Wasserman L M, Edson J R, Key N S, Chibbar R, McGlennen R C

Abstract excerpt

The Coagulation and Molecular Diagnostic laboratories at the University of Minnesota Medical School (Minneapolis) have collaborated to develop a diagnostic algorithm to identify all factor VLeiden mutation carriers without performing unnecessary and expensive genetic testing. The algorithm uses a coagulation assay for activated protein C resistance (APCR) to determine the need for genetic testing. We report the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to DNA
Share to Factor V

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Polymerase Chain Reaction

Share to Predictive Value of Tests

Share to Reference Values

Share to Sensitivity and Specificity

Source

Identifiers

PMID: 9322597
DOI: 10.1093/ajcp/108.4.427

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Detection of the factor VLeiden mutation. Development of a testing algorithm combining a coagulation assay and molecular diagnosis.PMID 9322597Read ↗

Molecular detection of a common mutation in coagulation factor V causing thrombosis via hereditary resistance to activated protein C.Semantic proximity Read ↗

An improved algorithm for activated protein C resistance and factor V Leiden screening.Semantic proximity Read ↗

ARMS test for diagnosis of factor VLeiden mutation, a common cause of inherited thrombotic tendency.Semantic proximity Read ↗

Detection of a common mutation in factor V gene responsible for resistance to activate protein C causing predisposition to thrombosis.Semantic proximity Read ↗

A matrix-assisted laser desorption/ionization time-of-flight based method for screening the 1691G --> A mutation in the factor V gene.Semantic proximity Read ↗

Discrimination between normal wildtype and carriers of coagulation factor V Leiden mutation by the activated protein C resistance test in the presence of factor V deficient plasma.Semantic proximity Read ↗

Sensitivity and specificity of the APC resistance assay in detection of individuals with factor V Leiden.Semantic proximity Read ↗

Two novel factor V null mutations associated with activated protein C resistance phenotype/genotype discrepancy.Semantic proximity Read ↗

Evaluation of temperature gradient capillary electrophoresis for detection of the Factor V Leiden mutation: coincident identification of a novel polymorphism in Factor V.Semantic proximity Read ↗

Screening with the activated protein C resistance assay yields significant savings in a patient population with low prevalence of factor V leiden.Semantic proximity Read ↗

The use of two different APC resistance assay systems provides optimal sensitivity and specificity for diagnosing genetic APC resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.