Article
Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes.
Nature - 26 Aug 1993
Rothe J, Lesslauer W, Lötscher H, Lang Y, Koebel P, Köntgen F, Althage A, Zinkernagel R, Steinmetz M, Bluethmann H
Abstract excerpt
Tumour necrosis factor (TNF), jointly referring to TNF alpha and TNF beta, is a central mediator of immune and inflammatory responses; its activities are mediated by two distinct receptors, TNFR1 (p55) and TNFR2 (p75) (reviewed in refs 1-3). The cytoplasmic domains of the TNFRs are unrelated, sug...
Topics
- Animals
- Antibodies
- Cell Line
- Chimera
- Disease Susceptibility
- Female
- Galactosamine
- Lipopolysaccharides
- Listeria monocytogenes
- Listeriosis
- Lymphocyte Subsets
- Male
- Mice
- Mice, Inbred C57BL
- Mutation