Article
Arabidopsis ribonucleotide reductases are critical for cell cycle progression, DNA damage repair, and plant development.
The Plant cell - 1 Feb 2006
Wang Chunxin, Liu Zhongchi
Abstract excerpt
Ribonucleotide reductase (RNR), comprising two large (R1) and two small (R2) subunits, catalyzes a rate-limiting step in the production of deoxyribonucleotides needed for DNA replication and repair. Previous studies in yeast and mammals indicated that defective RNR often led to cell cycle arrest, growth retardation, and p53-dependent apoptosis, whereas abnormally increased RNR activities led to higher mutation...
Topics
- Amino Acid Sequence
- Apoptosis
- Arabidopsis
- Arabidopsis Proteins
- Cell Cycle
- DNA Damage
- DNA Repair
- Gene Expression Profiling
- Gene Expression Regulation, Developmental
- Gene Expression Regulation, Plant
- Gene Silencing
- Genes, Plant
- Molecular Sequence Data
- Mutation