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Article

Arabidopsis ribonucleotide reductases are critical for cell cycle progression, DNA damage repair, and plant development.

The Plant cell - 1 Feb 2006

Wang Chunxin, Liu Zhongchi

Abstract excerpt

Ribonucleotide reductase (RNR), comprising two large (R1) and two small (R2) subunits, catalyzes a rate-limiting step in the production of deoxyribonucleotides needed for DNA replication and repair. Previous studies in yeast and mammals indicated that defective RNR often led to cell cycle arrest, growth retardation, and p53-dependent apoptosis, whereas abnormally increased RNR activities led to higher mutation...

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Identifiers

PMID: 16399800
DOI: 10.1105/tpc.105.037044
PMCID: PMC1356544

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Arabidopsis ribonucleotide reductases are critical for cell cycle progression, DNA damage repair, and plant development.PMID 16399800Read ↗

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Rice virescent3 and stripe1 encoding the large and small subunits of ribonucleotide reductase are required for chloroplast biogenesis during early leaf development.Semantic proximity Read ↗

The paralogous genes RADICAL-INDUCED CELL DEATH1 and SIMILAR TO RCD ONE1 have partially redundant functions during Arabidopsis development.Semantic proximity Read ↗

Analysis of Arabidopsis <i>venosa4-0</i> supports the role of VENOSA4 in dNTP homeostasisSemantic proximity Read ↗

Ribonucleotide reductases: amazing and confusing.Semantic proximity Read ↗

Conserved electron donor complex Dre2-Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesis.Semantic proximity Read ↗

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A DNA2 Homolog Is Required for DNA Damage Repair, Cell Cycle Regulation, and Meristem Maintenance in Plants.Semantic proximity Read ↗

Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase.Semantic proximity Read ↗

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