Article
The Drosophila DCO mutation suppresses age-related memory impairment without affecting lifespan.
Nature neuroscience - 1 Apr 2007
Yamazaki Daisuke, Horiuchi Junjiro, Nakagami Yasuko, Nagano Shintaro, Tamura Takuya, Saitoe Minoru
Abstract excerpt
The study of age-related memory impairment (AMI) has been hindered by a lack of AMI-specific mutants. In a screen for such mutants in Drosophila melanogaster, we found that heterozygous mutations of DCO (DCO/+), which encodes the major catalytic subunit of cAMP-dependent protein kinase (PKA), delay AMI more than twofold without affecting lifespan or memory at early ages. AMI is restored when a DCO transgene is...
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