Article
NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily.
Science (New York, N.Y.) - 3 Oct 1997
von Bülow G U, Bram R J
Abstract excerpt
Activation of the nuclear factor of activated T cells transcription factor (NF-AT) is a key event underlying lymphocyte action. The CAML (calcium-modulator and cyclophilin ligand) protein is a coinducer of NF-AT activation when overexpressed in Jurkat T cells. A member of the tumor necrosis factor receptor superfamily was isolated by virtue of its affinity for CAML. Cross-linking of this lymphocyte-specific...
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