Article
Mechanism of action of transmembrane activator and calcium modulator ligand interactor-Ig in murine systemic lupus erythematosus.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2004
Ramanujam Meera, Wang Xiaobo, Huang Weiqing, Schiffer Lena, Grimaldi Christine, Akkerman Alla, Diamond Betty, Madaio Michael P, Davidson Anne
Abstract excerpt
B cell-activating factor belonging to the TNF family (BAFF) blockade prevents the onset of disease in systemic lupus erythematosus (SLE)-prone NZB/NZW F(1) mice. To determine the mechanism of this effect, we administered a short course of TACI-Ig with and without six doses of CTLA4-Ig to 18- to 20-wk-old NZB/NZW F(1) mice and evaluated the effect on B and T cell subsets and on anti-dsDNA Ab-producing B cells....
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