Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Continuous autotropic signaling by membrane-expressed tumor necrosis factor.

The Journal of biological chemistry - 18 Jun 1999

Haas E, Grell M, Wajant H, Scheurich P

Abstract excerpt

Tumor necrosis factor (TNF) exists in two bioactive forms, the membrane-integrated form and the proteolytically derived soluble cytokine. Cells that produce TNF are often responsive to TNF, allowing autocrine/juxtacrine feedback loops. However, whether the membrane form of TNF is involved in such regulatory circuits is unclear. Here we demonstrate that HeLa cells, expressing a permanently membrane-integrated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Chloromethyl Ketones
Share to Calcium-Calmodulin-Dependent Protein Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Caspases

Share to Cycloheximide

Share to Mitogen-Activated Protein Kinases

Share to NF-kappa B

Share to p38 Mitogen-Activated Protein Kinases

Share to Receptors, Tumor Necrosis Factor

Source

Identifiers

PMID: 10364265
DOI: 10.1074/jbc.274.25.18107

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Continuous autotropic signaling by membrane-expressed tumor necrosis factor.PMID 10364265Read ↗

Autocrine tumor necrosis factor (TNF) and lymphotoxin (LT) alpha differentially modulate cellular sensitivity to TNF/LT-alpha cytotoxicity in L929 cells.Semantic proximity Read ↗

The Response of Human Epithelial Cells to TNF Involves an Inducible Autocrine CascadeSemantic proximity Read ↗

Cross-talk between receptor tyrosine kinase and tumor necrosis factor-α signaling networks regulates apoptosis but not proliferation.Semantic proximity Read ↗

Intracellular regulation of TNF activity in health and diseaseSemantic proximity Read ↗

The cybernetics of TNF: Old views and newer onesSemantic proximity Read ↗

A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral ProteinsSemantic proximity Read ↗

A nonsecretable cell surface mutant of tumor necrosis factor (TNF) kills by cell-to-cell contact.Semantic proximity Read ↗

Polyubiquitinated tristetraprolin protects from TNF-induced, caspase-mediated apoptosis.Semantic proximity Read ↗

Unraveling the intracellular cross-talk governing the balance between TNF <i>α</i> mediated survival and apoptosis signalingSemantic proximity Read ↗

Evidence for serpinB2-independent protection from TNF-alpha-induced apoptosis.Semantic proximity Read ↗

Production and characterization of receptor-specific TNF muteins.Semantic proximity Read ↗

A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative p55/p75 TNF receptor signalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.