Calcium-dependent cyclosporin A-sensitive activation of the interleukin-2 promoter by p56lck.

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Article

Calcium-dependent cyclosporin A-sensitive activation of the interleukin-2 promoter by p56lck.

The Journal of biological chemistry - 25 Apr 1993

Baldari C T, Heguy A, Telford J L

Abstract excerpt

T-cell antigen receptor engagement results in suboptimal activation of protein kinase C and a prolonged increase in intracellular free calcium concentration. These signals, in combination with stimulation via accessory molecules usually supplied by the antigen presenting cell, activate expression...

Topics

Calcium
Cell Line
Cyclosporine
Gene Expression Regulation
Humans
Interleukin-2
Lymphocyte Activation
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
Mutation
Promoter Regions, Genetic
Protein-Tyrosine Kinases
Signal Transduction
T-Lymphocytes
Transfection

Source

Open in PubMed

Identifiers

PMID: 8473282

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8473282-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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