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Targeted DNA Mutagenesis for the Cure of Chronic Viral Infections

21 Jun 2012

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1), hepatitis B virus (HBV), and herpes simplex virus (HSV) have been incurable to date because effective antiviral therapies target only replicating viruses and do not eradicate latently integrated or nonreplicating episomal viral genomes. Endonucleases that can target and cleave critical regions within latent viral genomes are currently in development. These enzymes are...

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PMID: 22718830
DOI: 10.1128/jvi.00052-12

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