Evolution of mouse hepatitis virus (MHV) during chronic infection: quasispecies nature of the persisting MHV RNA.

doi:10.1006/viro.1995.1265

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Article

Evolution of mouse hepatitis virus (MHV) during chronic infection: quasispecies nature of the persisting MHV RNA.

Virology - 1 Jun 1995

Adami C, Pooley J, Glomb J, Stecker E, Fazal F, Fleming J O, Baker S C

Abstract excerpt

Coronavirus infection of mice has been used extensively as a model for the study of acute encephalitis and chronic demyelination. To examine the evolution of coronavirus RNA during chronic demyelinating infection, we isolated RNA from intracerebrally inoculated mice at 4, 6, 8, 13, 20, and 42 days postinfection and used reverse transcription-polymerase chain reaction amplification methods (RT-PCR) to detect viral...

Topics

Amino Acid Sequence
Animals
Base Sequence
Biological Evolution
Brain
Cell Line
Cloning, Molecular
Codon
DNA Primers
DNA, Complementary
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hepatitis, Viral, Animal

Male

Mice

Mice, Inbred C57BL

Molecular Sequence Data

Murine hepatitis virus

Point Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 7778268
DOI: 10.1006/viro.1995.1265
PMCID: PMC7131440

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7778268-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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