Article
Mutations associated with viral sequences isolated from mice persistently infected with MHV-JHM.
Advances in experimental medicine and biology - 1 Jan 1995
Fleming J O, Adami C, Pooley J, Glomb J, Stecker E, Fazal F, Baker S C
Abstract excerpt
Mouse hepatitis virus JHM (JHMV or MHV-4) induces subacute and chronic demyelination in rodents and has been studied as a model human demyelinating diseases, such a multiple sclerosis. However, despite intensive investigation, the state of JHMV during chronic disease is poorly understood. Using r...
Topics
- Animals
- Biological Evolution
- Brain
- Chronic Disease
- Coronavirus Infections
- DNA Primers
- Genome, Viral
- Humans
- Male
- Mice
- Mice, Inbred C57BL
- Models, Genetic
- Murine hepatitis virus
- Mutation
- Polymerase Chain Reaction
- RNA, Viral
- Rodentia
- Time Factors