Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations associated with viral sequences isolated from mice persistently infected with MHV-JHM.

Advances in experimental medicine and biology - 1 Jan 1995

Fleming J O, Adami C, Pooley J, Glomb J, Stecker E, Fazal F, Baker S C

Abstract excerpt

Mouse hepatitis virus JHM (JHMV or MHV-4) induces subacute and chronic demyelination in rodents and has been studied as a model human demyelinating diseases, such a multiple sclerosis. However, despite intensive investigation, the state of JHMV during chronic disease is poorly understood. Using reverse transcription-polymerase chain reaction amplification (RT-PCR) to "rescue" viral RNA, we have found that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Evolution
Share to DNA Primers
Share to Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Models, Genetic

Share to Mutation

Share to Polymerase Chain Reaction

Share to RNA, Viral

Source

Identifiers

PMID: 8830547
DOI: 10.1007/978-1-4615-1899-0_94

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations associated with viral sequences isolated from mice persistently infected with MHV-JHM.PMID 8830547Read ↗

Variability of persisting MHV RNA sequences constituting immune and replication-relevant domains.Semantic proximity Read ↗

Cytotoxic T-cell-resistant variants arise at early times after infection in C57BL/6 but not in SCID mice infected with a neurotropic coronavirus.Semantic proximity Read ↗

Evolution of mouse hepatitis virus (MHV) during chronic infection: quasispecies nature of the persisting MHV RNA.Semantic proximity Read ↗

Role of CTL mutants in demyelination induced by mouse hepatitis virus, strain JHM.Semantic proximity Read ↗

Cytotoxic T cell-resistant variants are selected in a virus-induced demyelinating disease.Semantic proximity Read ↗

Infection with cytotoxic T-lymphocyte escape mutants results in increased mortality and growth retardation in mice infected with a neurotropic coronavirus.Semantic proximity Read ↗

Murine hepatitis virus JHM variants isolated from Wistar Furth rats with viral-induced neurological disease.Semantic proximity Read ↗

Characterization of brain-infiltrating mononuclear cells during infection with mouse hepatitis virus strain JHM.Semantic proximity Read ↗

Characterization of a variant virus from ascitic fluid of subacute granulomatous serositis in interferon-gamma-deficient C57BL/6 mice persistently infected with murine coronavirus strain JHM.Semantic proximity Read ↗

Both Spike and Background Genes Contribute to Murine Coronavirus NeurovirulenceSemantic proximity Read ↗

Receptor-independent infection by mutant viruses newly isolated from the neuropathogenic mouse hepatitis virus srr7 detected through a combination of spinoculation and ultraviolet radiation.Semantic proximity Read ↗

Immune-Mediated Control of a Dormant Neurotropic RNA Virus InfectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.