Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Crystal structures of engrailed homeodomain mutants: implications for stability and dynamics.

The Journal of biological chemistry - 31 Oct 2003

Stollar Elliott J, Mayor Ugo, Lovell Simon C, Federici Luca, Freund Stefan M V, Fersht Alan R, Luisi Ben F

Abstract excerpt

We report the crystal structures and biophysical characterization of two stabilized mutants of the Drosophila Engrailed homeodomain that have been engineered to minimize electrostatic repulsion. Four independent copies of each mutant occupy the crystal lattice, and comparison of these structures...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Crystallography, X-Ray
Share to Hydrogen
Share to Indoles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leucine

Share to Magnetic Resonance Spectroscopy

Share to Tryptophan

Source

Identifiers

PMID: 12923178
DOI: 10.1074/jbc.M308029200

Genes

ARX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12923178-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Crystal structures of engrailed homeodomain mutants: implications for stability and dynamics.PMID 12923178Read ↗

Electrostatics significantly affect the stability of designed homeodomain variants.Semantic proximity Read ↗

Engrailed (Gln50-->Lys) homeodomain-DNA complex at 1.9 A resolution: structural basis for enhanced affinity and altered specificity.Semantic proximity Read ↗

The denatured state of Engrailed Homeodomain under denaturing and native conditions.Semantic proximity Read ↗

Protein environment affects the water-tryptophan binding mode. MD, QM/MM, and NMR studies of engrailed homeodomain mutants.Semantic proximity Read ↗

A phage display selection of engrailed homeodomain mutants and the importance of residue Q50.Semantic proximity Read ↗

Structural studies of the Msx-1 homeodomain-DNA complex I.Semantic proximity Read ↗

Computational design and experimental verification of a symmetric protein homodimer.Semantic proximity Read ↗

The helix-turn-helix motif as an ultrafast independently folding domain: the pathway of folding of Engrailed homeodomain.Semantic proximity Read ↗

Engineered improvements in DNA-binding function of the MATa1 homeodomain reveal structural changes involved in combinatorial control.Semantic proximity Read ↗

Conformational variability of the intracellular domain of Drosophila Notch and its interaction with Suppressor of Hairless.Semantic proximity Read ↗

Solution structure of the LIM-homeodomain transcription factor complex Lhx3/Ldb1 and the effects of a pituitary mutation on key Lhx3 interactions.Semantic proximity Read ↗

Specific DNA recognition by the Antp homeodomain: MD simulations of specific and nonspecific complexes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.