Conservation and diversification in homeodomain-DNA interactions: a comparative genetic analysis.

doi:10.1073/pnas.93.14.6886

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Article

Conservation and diversification in homeodomain-DNA interactions: a comparative genetic analysis.

Proceedings of the National Academy of Sciences of the United States of America - 9 Jul 1996

Wilson D S, Sheng G, Jun S, Desplan C

Abstract excerpt

Nearly all metazoan homeodomains (HDs) possess DNA binding targets that are related by the presence of a TAAT sequence. We use an in vitro genetic DNA binding site selection assay to refine our understanding of the amino acid determinants for the recognition of the TAAT site. Superimposed upon th...

Topics

Amino Acid Sequence
Animals
Base Sequence
Binding Sites
Conserved Sequence
DNA, Protozoan
Eukaryota
Genetic Variation
Glutathione Transferase
Homeodomain Proteins
Models, Molecular
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleic Acid Conformation

Oligodeoxyribonucleotides

Protein Structure, Secondary

Recombinant Fusion Proteins

Sequence Homology, Amino Acid

Substrate Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 8692913
DOI: 10.1073/pnas.93.14.6886
PMCID: PMC38903

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8692913-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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