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Article

Nearest neighbor analysis of the SecYEG complex. 1. Identification of a SecY-SecG interface.

Biochemistry - 24 Jun 2003

Satoh Yasunari, Matsumoto Gen, Mori Hiroyuki, Ito Koreaki

Abstract excerpt

Integral membrane components SecY, SecE, and SecG of protein translocase form a complex in the Escherichia coli plasma membrane. To characterize subunit interactions of the SecYEG complex, a series of SecY variants having a single cysteine in its cytoplasmic (C1-C6) or periplasmic (P1-P5) domain were subjected to site-specific cross-linking experiments using bifunctional agents with thiol-amine reactivity....

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Source

Identifiers

PMID: 12809499
DOI: 10.1021/bi034331a

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nearest neighbor analysis of the SecYEG complex. 1. Identification of a SecY-SecG interface.PMID 12809499Read ↗

SecY-SecY and SecY-SecG contacts revealed by site-specific crosslinking.Semantic proximity Read ↗

Mutational analysis of transmembrane regions 3 and 4 of SecY, a central component of protein translocase.Semantic proximity Read ↗

Two SecG molecules present in a single protein translocation machinery are functional even after crosslinking.Semantic proximity Read ↗

A SecE mutation that modulates SecY-SecE translocase assembly, identified as a specific suppressor of SecY defects.Semantic proximity Read ↗

Bacterial protein translocation requires only one copy of the SecY complex in vivo.Semantic proximity Read ↗

In vivo membrane topology of Escherichia coli SecA ATPase reveals extensive periplasmic exposure of multiple functionally important domains clustering on one face of SecA.Semantic proximity Read ↗

Mapping an interface of SecY (PrlA) and SecE (PrlG) by using synthetic phenotypes and in vivo cross-linking.Semantic proximity Read ↗

A cytoplasmic domain is important for the formation of a SecY-SecE translocator complex.Semantic proximity Read ↗

Translocation of proteins through the Sec61 and SecYEG channels.Semantic proximity Read ↗

SecY and SecA interact to allow SecA insertion and protein translocation across the Escherichia coli plasma membrane.Semantic proximity Read ↗

Molecular architecture of the ER translocase probed by chemical crosslinking of Sss1p to complementary fragments of Sec61p.Semantic proximity Read ↗

Dimeric SecA is essential for protein translocation.Semantic proximity Read ↗

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