Article
Pathophysiological mechanisms of dominant and recessive KVLQT1 K+ channel mutations found in inherited cardiac arrhythmias.
Human molecular genetics - 1 Oct 1997
Wollnik B, Schroeder B C, Kubisch C, Esperer H D, Wieacker P, Jentsch T J
Abstract excerpt
The inherited long QT syndrome (LQTS), characterized by a prolonged QT interval in the electrocardiogram and cardiac arrhythmia, is caused by mutations in at least four different genes, three of which have been identified and encode cardiac ion channels. The most common form of LQTS is due to mut...
Topics
- Amino Acid Sequence
- Base Sequence
- Cloning, Molecular
- DNA, Complementary
- Female
- Genes, Dominant
- Genes, Recessive
- Humans
- KCNQ Potassium Channels
- KCNQ1 Potassium Channel
- Long QT Syndrome
- Male
- Molecular Sequence Data
- Mutation
- Pedigree
- Potassium Channels
- Potassium Channels, Voltage-Gated