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Article

Molecular pathogenesis of long QT syndrome type 1

27 Jan 2016

Abstract excerpt

Abstract Long QT syndrome type 1 (LQT1) is a subtype of a congenital cardiac syndrome caused by mutation in the KCNQ1 gene, which encodes the α‐subunit of the slow component of delayed rectifier K+ current (IKs) channel. Arrhythmias in LQT1 are characterized by prolongation of the QT interval on ECG, as well as the occurrence of life‐threatening cardiac events, frequently triggered by adrenergic stimuli (e.g.,...

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PMID: 27761162
DOI: 10.1016/j.joa.2015.12.006

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