Article
Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias.
The EMBO journal - 1 Sept 1997
Chouabe C, Neyroud N, Guicheney P, Lazdunski M, Romey G, Barhanin J
Abstract excerpt
Mutations in the delayed rectifier K+ channel subunit KvLQT1 have been identified as responsible for both Romano-Ward (RW) and Jervell and Lange-Nielsen (JLN) inherited long QT syndromes. We report the molecular cloning of a human KvLQT1 isoform that is expressed in several human tissues includin...
Topics
- Amino Acid Sequence
- Animals
- COS Cells
- Cloning, Molecular
- DNA, Complementary
- Electrophysiology
- Humans
- KCNQ Potassium Channels
- KCNQ1 Potassium Channel
- Long QT Syndrome
- Models, Molecular
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Phenotype