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Article

Molecular Mechanism of Autosomal Recessive Long QT-Syndrome 1 without Deafness.

International journal of molecular sciences - 23 Jan 2021

Oertli Annemarie, Rinné Susanne, Moss Robin, Kääb Stefan, Seemann Gunnar, Beckmann Britt-Maria, Decher Niels

Abstract excerpt

KCNQ1 encodes the voltage-gated potassium (Kv) channel KCNQ1, also known as KvLQT1 or Kv7.1. Together with its ß-subunit KCNE1, also denoted as minK, this channel generates the slowly activating cardiac delayed rectifier current IKs, which is a key regulator of the heart rate dependent adaptation of the cardiac action potential duration (APD). Loss-of-function mutations in KCNQ1 cause congenital long QT1 (LQT1)...

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Identifiers

PMID: 33498651
DOI: 10.3390/ijms22031112
PMCID: PMC7865240

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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