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Article

Dominant-Negative <i>KvLQT1</i> Mutations Underlie the LQT1 Form of Long QT Syndrome

16 Sept 1997

Abstract excerpt

BACKGROUND: Mutations that map to the KvLQT1 gene on human chromosome 11 account for more than 50% of inherited long QT syndrome (LQTS). It has been discovered recently that the KvLQT1 and minK proteins functionally interact to generate a current with biophysical properties similar to I(Ks), the slowly activating delayed-rectifier cardiac potassium current. Since I(Ks) modulates the repolarization of cardiac...

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PMID: 9323054
DOI: 10.1161/01.cir.96.6.1733

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Related research

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Dominant-Negative <i>KvLQT1</i> Mutations Underlie the LQT1 Form of Long QT SyndromePMID 9323054Read ↗

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