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Article

Dysfunction of delayed rectifier potassium channels in an inherited cardiac arrhythmia.

Annals of the New York Academy of Sciences - 30 Apr 1999

Sanguinetti M C

Abstract excerpt

The rapid (IKr) and slow (IKs) delayed rectifier K+ currents are key regulators of cardiac repolarization. HERG encodes the Kr channel, and KVLQT1 and hminK encode subunits that coassemble to form Ks channels. Mutations in any one of these genes cause Romano-Ward syndrome, an autosomal dominant form of long QT syndrome (LQT). Mutations in KVLQT1 and HERG are the most common cause of LQT. Not all missense...

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Source

Identifiers

PMID: 10414310
DOI: 10.1111/j.1749-6632.1999.tb11302.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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