Article
ExoU expression by Pseudomonas aeruginosa correlates with acute cytotoxicity and epithelial injury.
Molecular microbiology - 1 Aug 1997
Finck-Barbançon V, Goranson J, Zhu L, Sawa T, Wiener-Kronish J P, Fleiszig S M, Wu C, Mende-Mueller L, Frank D W
Abstract excerpt
The production of exoenzyme S is correlated with the ability of Pseudomonas aeruginosa to disseminate from epithelial colonization sites and cause a fatal sepsis in burn injury and acute lung infection models. Exoenzyme S is purified from culture supernatants as a non-covalent aggregate of two polypeptides, ExoS and ExoT. ExoS and ExoT are encoded by separate but highly similar genes, exoS and exoT. Clinical...
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