Article
ExoU expression by Pseudomonas aeruginosa correlates with acute cytotoxicity and epithelial injury.
Molecular microbiology - 1 Aug 1997
Finck-Barbançon V, Goranson J, Zhu L, Sawa T, Wiener-Kronish J P, Fleiszig S M, Wu C, Mende-Mueller L, Frank D W
Abstract excerpt
The production of exoenzyme S is correlated with the ability of Pseudomonas aeruginosa to disseminate from epithelial colonization sites and cause a fatal sepsis in burn injury and acute lung infection models. Exoenzyme S is purified from culture supernatants as a non-covalent aggregate of two po...
Topics
- ADP Ribose Transferases
- Amino Acid Sequence
- Animals
- Bacterial Proteins
- Bacterial Toxins
- Cell Line
- Chromosome Mapping
- Cloning, Molecular
- Cytotoxins
- DNA-Binding Proteins
- Dogs
- Genes, Bacterial
- Humans
- Lung Injury
- Mice