Comparable radiation sensitivity in p53 wild-type and p53 deficient tumor cells associated with different cell death modalities

Abstract excerpt

Abstract Studies of radiation interaction with tumor cells often take apoptosis as the desired results. However, mitotic catastrophe and senescence are also promoted by clinically relevant doses of radiation. Furthermore, p53 is a well-known transcription factor that is closely associated with radiosensitivity and radiation-induced cell death. Therefore, we aimed to investigate the involvement of...

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