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Article

A peptide DNA surrogate accelerates autoimmune manifestations and nephritis in lupus-prone mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2002

Beger Erik, Deocharan Bisram, Edelman Morris, Erblich Bryna, Gu Yun, Putterman Chaim

Abstract excerpt

Lupus-associated anti-DNA Abs display features of Ag selection, yet the triggering Ag in the disease is unknown. We previously demonstrated that the peptide DWEYSVWLSN is bound by a pathogenic anti-DNA Ab, and that immunization of nonautoimmune mice with this peptide induces autoantibodies and renal Ig deposition. To elucidate differences in the induced B cell responses in mice genetically predisposed to...

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Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain
Share to Gene Rearrangement, B-Lymphocyte, Light Chain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Injections, Subcutaneous

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Source

Identifiers

PMID: 11907127
DOI: 10.4049/jimmunol.168.7.3617

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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