Article
Common and individual features of the humoral immunity dysregulation of mice homozygous at the viable motheaten (mev) mutation.
Immunology letters - 1 May 1990
Kuntz L, Fonteneau P, Loor F
Abstract excerpt
The "viable motheaten" (mev) mutation in the C57BL/6 (B6) mouse causes in mev-homozygous B6 mice a rapidly progressing and fatal autoimmune syndrome, combined with a generalized immunodeficiency. Serological analyses of a large number of mev/mev individual mice revealed profound abnormalities of...
Topics
- Animals
- Antibody Formation
- Autoantibodies
- Autoimmune Diseases
- Female
- Genetic Variation
- Homozygote
- Hypergammaglobulinemia
- Immunity, Innate
- Immunoglobulin Isotypes
- Immunologic Deficiency Syndromes
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains