Article
Partial expression of the viable motheaten (mev) mutation in the heterozygous state: abnormal levels of serum immunoglobulins and natural anti-ssDNA antibodies.
Journal of autoimmunity - 1 Jun 1990
Kuntz L, Fonteneau P, Loor F
Abstract excerpt
The 'viable motheaten' (mev) mutation in the C57BL/6 (B6) mouse causes a rapidly progressive and fatal autoimmune syndrome in mev-homozygous B6 mice, combined with generalized immunodeficiency, whereas the mev-heterozygous B6 mice look phenotypically normal. However, serological analyses of the l...
Topics
- Animals
- Antibodies, Antinuclear
- Autoimmune Diseases
- DNA, Single-Stranded
- Enzyme-Linked Immunosorbent Assay
- Female
- Gene Expression
- Heterozygote
- Immunoglobulin Heavy Chains
- Immunoglobulin Isotypes
- Male
- Mice
- Mice, Inbred C57BL
- Mutation