Partial expression of the viable motheaten (mev) mutation in the heterozygous state: abnormal levels of serum immunoglobulins and natural anti-ssDNA antibodies.

Abstract excerpt

The 'viable motheaten' (mev) mutation in the C57BL/6 (B6) mouse causes a rapidly progressive and fatal autoimmune syndrome in mev-homozygous B6 mice, combined with generalized immunodeficiency, whereas the mev-heterozygous B6 mice look phenotypically normal. However, serological analyses of the levels of some spontaneously occurring, natural antibodies and of the levels and distribution of the different classes...

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