Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Oct 1997

Kretzschmar D, Hasan G, Sharma S, Heisenberg M, Benzer S

Abstract excerpt

Swiss cheese (sws) mutant flies develop normally during larval life but show age-dependent neurodegeneration in the pupa and adult and have reduced life span. In late pupae, glial processes form abnormal, multilayered wrappings around neurons and axons. Degeneration first becomes evident in young flies as apoptosis in single scattered cells in the CNS, but later it becomes severe and widespread. In the adult, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Brain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosome Mapping

Share to Drosophila

Share to Drosophila Proteins

Share to Molecular Sequence Data

Share to Mutation

Share to RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 9295388
PMCID: PMC6573436

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila.PMID 9295388Read ↗

Loss of Swiss cheese/neuropathy target esterase activity causes disruption of phosphatidylcholine homeostasis and neuronal and glial death in adult Drosophila.Semantic proximity Read ↗

blue cheese mutations define a novel, conserved gene involved in progressive neural degeneration.Semantic proximity Read ↗

Unraveling the link between Neuropathy Target Esterase NTE/SWS, lysosomal storage diseases, inflammation, and abnormal fatty acid metabolismSemantic proximity Read ↗

The cyclic nucleotide binding sites of Swiss-Cheese, the <i>Drosophila</i> orthologue of human PNPLA6, are required for its catalytic functionSemantic proximity Read ↗

Mutations in the novel membrane protein spinster interfere with programmed cell death and cause neural degeneration in Drosophila melanogaster.Semantic proximity Read ↗

Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles.Semantic proximity Read ↗

<i>Drosophila Bchs</i> overexpression recapitulates human <i>WDFY3</i> neurodevelopmental phenotypes with implications for glial cell involvement in altered head circumferenceSemantic proximity Read ↗

Ceramides And Stress Signalling Intersect With Autophagic Defects In Neurodegenerative Drosophila blue cheese (bchs) Mutants.Semantic proximity Read ↗

Genetic Disruption of WASHC4 Drives Endo-lysosomal Dysfunction and Cognitive-Movement Impairments in Mice and HumansSemantic proximity Read ↗

Swiss Cheese, a protein involved in progressive neurodegeneration, acts as a noncanonical regulatory subunit for PKA-C3.Semantic proximity Read ↗

Delayed Induction of Human NTE (PNPLA6) Rescues Neurodegeneration and Mobility Defects of Drosophila swiss cheese (sws) Mutants.Semantic proximity Read ↗

A <i>Drosophila</i> screen of schizophrenia-related genes highlights the requirement of neural and glial matrix metalloproteinases for neuronal remodelingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.