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Unraveling the link between Neuropathy Target Esterase NTE/SWS, lysosomal storage diseases, inflammation, and abnormal fatty acid metabolism

2023-08-12

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in Drosophila Swiss Cheese (SWS) gene or its vertebrate orthologue Neuropathy Target Esterase (NTE) lead to progressive neuronal degeneration in flies and humans. Despite its enzymatic function as a phospholipase is well-established, the molecular mechanism responsible for maintaining nervous system integrity remains unclear. In this study, we found that SWS is present in surface glia...

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Literature Corpus work
09b715c4-9107-50b2-a223-e0d993a70aee
DOI
10.1101/2023.08.11.552934
Open publication

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Unraveling the link between Neuropathy Target Esterase NTE/SWS, lysosomal storage diseases, inflammation, and abnormal fatty acid metabolismDOI 10.1101/2023.08.11.552934
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