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Article

Loss of Swiss cheese/neuropathy target esterase activity causes disruption of phosphatidylcholine homeostasis and neuronal and glial death in adult Drosophila.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 16 Mar 2005

Mühlig-Versen Max, da Cruz Alexandre Bettencourt, Tschäpe Jakob-Andreas, Moser Markus, Büttner Reinhard, Athenstaedt Karin, Glynn Paul, Kretzschmar Doris

Abstract excerpt

The Drosophila Swiss cheese (sws) mutant is characterized by progressive degeneration of the adult nervous system, glial hyperwrapping, and neuronal apoptosis. The Swiss cheese protein (SWS) shares 39% sequence identity with human neuropathy target esterase (NTE), and a brain-specific deletion of SWS/NTE in mice causes a similar pattern of progressive neuronal degeneration. NTE reacts with organophosphate...

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Identifiers

PMID: 15772346
DOI: 10.1523/JNEUROSCI.5097-04.2005
PMCID: PMC1182176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Loss of Swiss cheese/neuropathy target esterase activity causes disruption of phosphatidylcholine homeostasis and neuronal and glial death in adult Drosophila.PMID 15772346Read ↗

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