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Article

The roles of the conserved tyrosine in the β2-α2 loop of the prion protein.

Prion - 1 Jan 2015

Huang Danzhi, Caflisch Amedeo

Abstract excerpt

Prions cause neurodegenerative diseases for which no cure exists. Despite decades of research activities the function of the prion protein (PrP) in mammalians is not known. Moreover, little is known on the molecular mechanisms of the self-assembly of the PrP from its monomeric state (cellular PrP, PrP(C)) to the multimeric state. The latter state includes the toxic species (scrapie PrP, PrP(Sc)) knowledge of...

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Identifiers

PMID: 26689486
DOI: 10.1080/19336896.2015.1115944
PMCID: PMC4964861

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