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Article

The charge structure of helix 1 in the prion protein regulates conversion to pathogenic PrPSc.

Journal of virology - 1 Sept 2006

Norstrom Eric M, Mastrianni James A

Abstract excerpt

The prion diseases are transmissible neurodegenerative disorders linked to a pathogenic conformer (PrP(Sc)) of the normal prion protein (PrP(C)). Accumulation of PrP(Sc) occurs via a poorly defined process in which PrP(Sc) complexes with and converts endogenous PrP(C) to nascent PrP(Sc). Recent experiments have focused on the highly charged first alpha helix (H1) of PrP. It has been proposed that two putative...

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Identifiers

PMID: 16912302
DOI: 10.1128/JVI.00366-06
PMCID: PMC1563859

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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