Article
Polymerase chain reaction-single-strand conformation polymorphism analysis for the VHL gene in chemically induced kidney tumors of rats using intron-derived primers.
Molecular carcinogenesis - 1 Aug 1997
Shiao Y H, Diwan B A, Perantoni A O, Calvert R J, Zbar B, Lerman M I, Rice J M
Abstract excerpt
von Hippel-Lindau (VHL) gene mutations occur throughout three exons including the exon-intron boundaries in human VHL disease-associated and sporadic renal cell carcinomas. To explore the possible role of the VHL gene in chemically induced rat kidney tumors originating from various cell types, mo...
Topics
- Animals
- Base Sequence
- DNA Primers
- DNA, Neoplasm
- Epithelium
- Exons
- Genetic Testing
- Introns
- Kidney Neoplasms
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Rats
- Rats, Inbred F344
- Wilms Tumor
- von Hippel-Lindau Disease