Article
Allelic deletions of the VHL gene detected in multiple microscopic clear cell renal lesions in von Hippel-Lindau disease patients.
The American journal of pathology - 1 Dec 1996
Lubensky I A, Gnarra J R, Bertheau P, Walther M M, Linehan W M, Zhuang Z
Abstract excerpt
Patients with von Hippel-Lindau (VHL) disease develop a spectrum of bilateral clear-cell renal lesions including cysts and renal cell carcinomas (RCCs). VHL gene deletions have been previously reported in VHL-associated macroscopic RCC. Although histological analysis suggests that microscopic cys...
Topics
- Adenocarcinoma, Clear Cell
- Adult
- Alleles
- Carcinoma, Renal Cell
- Genes, Tumor Suppressor
- Humans
- Kidney Diseases, Cystic
- Kidney Neoplasms
- Ligases
- Male
- Proteins
- Sequence Deletion
- Tumor Suppressor Proteins
- Ubiquitin-Protein Ligases
- Von Hippel-Lindau Tumor Suppressor Protein
- von Hippel-Lindau Disease