Article
von Hippel-Lindau gene mutations in N-nitrosodimethylamine-induced rat renal epithelial tumors.
Journal of the National Cancer Institute - 18 Nov 1998
Shiao Y H, Rice J M, Anderson L M, Diwan B A, Hard G C
Abstract excerpt
BACKGROUND: Mutations in the von Hippel-Lindau (VHL) gene are common in human clear cell kidney cancers. Carcinogens in cigarette smoke, especially nitrosamines, are known to induce kidney tumors of a variety of histologic types in rodents--but with no evidence of VHL mutations; however, none of...
Topics
- Adenocarcinoma, Clear Cell
- Animals
- Carcinogens
- DNA Mutational Analysis
- DNA Primers
- DNA, Neoplasm
- Female
- Kidney Neoplasms
- Mutation
- Nitroso Compounds
- Polymerase Chain Reaction
- Rats
- Rats, Wistar
- Smoking
- von Hippel-Lindau Disease