Article
von Hippel-Lindau gene mutations in N-nitrosodimethylamine-induced rat renal epithelial tumors.
Journal of the National Cancer Institute - 18 Nov 1998
Shiao Y H, Rice J M, Anderson L M, Diwan B A, Hard G C
Abstract excerpt
BACKGROUND: Mutations in the von Hippel-Lindau (VHL) gene are common in human clear cell kidney cancers. Carcinogens in cigarette smoke, especially nitrosamines, are known to induce kidney tumors of a variety of histologic types in rodents--but with no evidence of VHL mutations; however, none of these tumors resembled human clear cell carcinomas. We examined N-nitrosodimethylamine-induced kidney tumors of the...
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