Somatic mutations of von Hippel-Lindau (VHL) tumor-suppressor gene in European kidney cancers.

doi:10.1002/ijc.2910630510

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Article

Somatic mutations of von Hippel-Lindau (VHL) tumor-suppressor gene in European kidney cancers.

International journal of cancer - 27 Nov 1995

Bailly M, Bain C, Favrot M C, Ozturk M

Abstract excerpt

Somatic mutations of von Hippel Lindau (VHL) tumor-suppressor gene have been identified in kidney cancers from North America and Japan. We studied VHL gene mutation in 31 kidney tumors from France. Of these tumors, 45% (14/31) displayed mutations, 60% of which occurred at A:T base pairs. The freq...

Topics

Adult
Aged
Aged, 80 and over
Base Sequence
Breast Neoplasms
Carcinoma, Hepatocellular
Carcinoma, Renal Cell
Europe
Exons
Female
Genes, Tumor Suppressor
Humans
Kidney Neoplasms
Liver Neoplasms
Lymphocytes
Male
Middle Aged
Molecular Sequence Data

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