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Article

Expression of the von Hippel-Lindau disease tumour suppressor gene during human embryogenesis

1 May 1996

Abstract excerpt

The von Hippel-Lindau (VHL) disease product is thought to down-regulate transcription by antagonizing elongin-enhanced transcriptional elongation. Germline VHL gene mutations predispose to the development of retinal, cerebellar and spinal haemangioblastomas, renal cell carcinoma and phaeochromocytoma. In addition, somatic Inactivation of the VHL gene is frequent in sporadic renal cell carcinoma and...

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Identifiers

PMID: 8733131
DOI: 10.1093/hmg/5.5.639

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Expression of the von Hippel-Lindau disease tumour suppressor gene during human embryogenesisPMID 8733131Read ↗

Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene.Semantic proximity Read ↗

Defective placental vasculogenesis causes embryonic lethality in VHL-deficient miceSemantic proximity Read ↗

Renal cell carcinoma development in the rat independent of alterations at the VHL gene locus.Semantic proximity Read ↗

Inhibition of transcription elongation by the VHL tumor suppressor protein.Semantic proximity Read ↗

von Hippel-Lindau DiseaseSemantic proximity Read ↗

Polymerase chain reaction-single-strand conformation polymorphism analysis for the VHL gene in chemically induced kidney tumors of rats using intron-derived primers.Semantic proximity Read ↗

VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.Semantic proximity Read ↗

Alu elements in human growth hormone receptor gene 5' untranslated region exons.Semantic proximity Read ↗

Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein.Semantic proximity Read ↗

Tracheal development and the von Hippel-Lindau tumor suppressor homolog in Drosophila.Semantic proximity Read ↗

Mutation of the VHL gene is associated exclusively with the development of non-papillary renal cell carcinomas.Semantic proximity Read ↗

Endoplasmic reticulum/cytosolic localization of von Hippel-Lindau gene products is mediated by a 64-amino acid region.Semantic proximity Read ↗

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