Article
Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice.
Genetics - 1 Dec 1996
Gould K A, Luongo C, Moser A R, McNeley M K, Borenstein N, Shedlovsky A, Dove W F, Hong K, Dietrich W F, Lander E S
Abstract excerpt
As genetic mapping of quantitative trait loci (QTL) becomes routine, the challenge is to identify the underlying genes. This paper develops rigorous genetic tests for evaluation of candidate genes for a QTL, involving determination of allelic status in inbred strains and fine-structure genetic mapping. For the Mom1 modifier of intestinal adenomas caused by ApcMin, these tests are used to evaluate two candidate...
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